Lin28-let-7a antagonist 1
CAS No. 2024548-03-4
Lin28-let-7a antagonist 1 ( —— )
Catalog No. M26279 CAS No. 2024548-03-4
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
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10MG | 483 | In Stock |
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25MG | 782 | In Stock |
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50MG | 1071 | In Stock |
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100MG | 1431 | In Stock |
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200MG | Get Quote | In Stock |
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Biological Information
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Product NameLin28-let-7a antagonist 1
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NoteResearch use only, not for human use.
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Brief DescriptionLin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.
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DescriptionLin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.(In Vitro):When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM.?Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency.?Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA.?
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPEGs
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Research Area——
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Indication——
Chemical Information
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CAS Number2024548-03-4
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Formula Weight583.6
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Molecular FormulaC31H29N5O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1(C)Oc2cc(N3CCN(CC3)C(=O)OCc3ccccc3)c(cc2-c2c1cnn2-c1ccc(cc1)C(O)=O)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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